Lymphoepithelioma-like carcinoma of the endometrium: Case report of a rare tumour with comprehensive immunohistochemical and molecular analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376845" target="_blank" >RIV/00216208:11110/18:10376845 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/18:10376845
Result on the web
<a href="https://doi.org/10.5114/pjp.2018.75342" target="_blank" >https://doi.org/10.5114/pjp.2018.75342</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5114/pjp.2018.75342" target="_blank" >10.5114/pjp.2018.75342</a>
Alternative languages
Result language
angličtina
Original language name
Lymphoepithelioma-like carcinoma of the endometrium: Case report of a rare tumour with comprehensive immunohistochemical and molecular analysis
Original language description
We are reporting a case of endometrial lymphoepithelioma-like carcinoma (LELC) in a 63-year-old female. Microscopically, the tumor consisted of groups of tumor cells surrounded by dense lymphoplasmacytic infiltrate. Immunohistochemically, the tumour cells were positive for cytokeratins AE1/AE3, EMA, PAX8, p16, and estrogen receptors. Protein p53 showed an aberrant type of expression. Molecular genetic analysis revealed mutations in the TP53 and PIKP53CA genes. Based on our results, we believe that the tumor represents an unusual morphological variant of endometrial serous carcinoma.To the best of our knowledge, only six cases of LELC arising in endometrium have been reported in literature to date.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30106 - Anatomy and morphology (plant science to be 1.6)
Result continuities
Project
<a href="/en/project/NV17-28404A" target="_blank" >NV17-28404A: Analysis of expression, epigenetic and genetic changes of HNF1B in selected solid tumors</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polish Journal of Pathology
ISSN
1233-9687
e-ISSN
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Volume of the periodical
69
Issue of the periodical within the volume
1
Country of publishing house
PL - POLAND
Number of pages
6
Pages from-to
87-92
UT code for WoS article
000433094500011
EID of the result in the Scopus database
2-s2.0-85046767209