Low Cerebral Oxygenation Is Associated with Cognitive Impairment in Chronic Hemodialysis Patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376908" target="_blank" >RIV/00216208:11110/18:10376908 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/18:10376908

Result on the web

<a href="https://doi.org/10.1159/000487092" target="_blank" >https://doi.org/10.1159/000487092</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000487092" target="_blank" >10.1159/000487092</a>

Result language

angličtina

Original language name

Low Cerebral Oxygenation Is Associated with Cognitive Impairment in Chronic Hemodialysis Patients

Original language description

Background/Aims: High rates of cognitive impairment (CI) are an alarming problem in patients undergoing chronic hemodialysis (HD). Its pathophysiology remains unclear and there are indications that brain ischemia might be one of the key causes. Cerebral tissue oxygenation, as measured by near-infrared spectroscopy, is known to be decreased in HD patients. However, it is unknown whether CI is associated or not associated with lower cerebral oxygenation in these patients. The primary aim of our study was to probe this possible association. Our secondary aim was to assess other factors possibly related to cerebral ischemia and CI. Methods: Thirty-nine patients treated by chronic HD were included in this cross-sectional study. All measurements were performed before the initiation of an HD session. The Montreal Cognitive Assessment (MoCA) was administered according to published recommendations. Regional saturation of oxygen (rSO2) of the left frontal lobe was measured using the INVOS 5100C device. Basic medical history and laboratory data were recorded, and handgrip strength was analyzed. We used the unpaired t test to compare the rSO2 and other variables between cognitively normal patients (MoCA score &gt;= 26) and those who displayed CI (MoCA score &lt; 26). Multiple linear regression analysis was used to adjust for principal confounders. Results: Cognitively impaired patients had lower brain rSO2 values compared to cognitively normal patients (48 +/- 9 vs. 57 +/- 10%, p = 0.01). Among other variables, higher red cell distribution width (15.8 +/- 1.9 vs. 13.8 +/- 1.6%, p = 0.01) and lower hand grip strength (49.2 +/- 23.3 vs. 99.3 +/- 31.4 lbs, p &lt; 0.001) also displayed a significant association with CI. The relation between rSO2 and MoCA score was significant after adjustment for age and gender (p = 0.007). Conclusion: Decreased brain oxygenation is associated with weaker cognitive performance in patients undergoing chronic HD. Further understanding the causes of cerebral ischemia in HD patients could lead to the prevention of cognitive decline in this population.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30217 - Urology and nephrology

Project

<a href="/en/project/NV17-31796A" target="_blank" >NV17-31796A: Tissue hypoxia in patients with chronic kidney disease – metabolic and hemodynamic associations</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nephron

ISSN

1660-8151

e-ISSN

—

Volume of the periodical

139

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

113-119

UT code for WoS article

000433957700001

EID of the result in the Scopus database

2-s2.0-85042118011