Progressive Chronic Retinal Axonal Loss Following Acute Methanol-induced Optic Neuropathy: Four-Year Prospective Cohort Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10377111" target="_blank" >RIV/00216208:11110/18:10377111 - isvavai.cz</a>

Alternative codes found

RIV/61388955:_____/18:00497405 RIV/00216208:11510/18:10377111 RIV/00064165:_____/18:10377111

Result on the web

<a href="https://doi.org/10.1016/j.ajo.2018.04.015" target="_blank" >https://doi.org/10.1016/j.ajo.2018.04.015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ajo.2018.04.015" target="_blank" >10.1016/j.ajo.2018.04.015</a>

Result language

angličtina

Original language name

Progressive Chronic Retinal Axonal Loss Following Acute Methanol-induced Optic Neuropathy: Four-Year Prospective Cohort Study

Original language description

Purpose: To study the dynamics and clinical determinants of chronic retinal nerve fiber layer thickness (RNFL) loss after methanol-induced optic neuropathy. Design: Prospective cohort study. Methods: All patients underwent complete ophthalmic evaluation including spectral-domain optical coherence tomography 3 times during 4 years of observation: 4.9 (+-0.6), 25.0 (+-0.6), and 49.9 (+-0.5) months after discharge. Participants: Eighty-four eyes of 42 survivors of methanol poisoning, mean age (standard deviation) of 45.7 (+-4.4) years; and 82 eyes of 41 controls, mean age 44.0 (+-4.2) years. Main Outcome Measures: Global and temporal RNFL loss. Results: Abnormal RNFL thickness was registered in 13 of 42 (31%) survivors of methanol poisoning and chronic axonal loss in 10 of 42 (24%) patients. Significant decrease of global/temporal RNFL thickness during the observation period was found in the study population compared to the controls (P &lt; .001). The risk estimate of chronic global RNFL loss for arterial blood pH &lt; 7.3 at admission was 11.65 (95% confidence interval 1.91-71.12) after adjusting for age and sex. The patients with chronic axonal degeneration demonstrated progressive visual loss in 7 of 10 cases. The patients with abnormal RNFL thickness had magnetic resonance signs of brain damage in 10 of 13 vs 8 of 29 cases with normal RNFL thickness (P = .003). Signs of brain hemorrhages were present in 7 of 13 patients with abnormal RNFL thickness vs 5 of 29 cases with normal RNFL thickness (P = .015). Conclusions: Methanol-induced optic neuropathy may lead to chronic retinal axonal loss during the following years. Arterial blood pH on admission is the strongest predictor of chronic RNFL thickness decrease. Chronic retinal neurodegeneration is associated with the progressive loss of visual functions and necrotic brain lesions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30207 - Ophthalmology

Project

<a href="/en/project/NV16-27075A" target="_blank" >NV16-27075A: NEURODEGENERATIVE PROCESSES IN PATIENTS EXPOSED TO METHANOL: PROSPECTIVE STUDY AFTER CZECH MASS METHANOL POISONING OUTBREAK IN 2012</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

American Journal of Ophthalmology

ISSN

0002-9394

e-ISSN

—

Volume of the periodical

191

Issue of the periodical within the volume

July

Country of publishing house

US - UNITED STATES

Number of pages

16

Pages from-to

100-115

UT code for WoS article

000437387100018

EID of the result in the Scopus database

2-s2.0-85046725523