Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10378374" target="_blank" >RIV/00216208:11110/18:10378374 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s41467-018-05074-y" target="_blank" >https://doi.org/10.1038/s41467-018-05074-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-018-05074-y" target="_blank" >10.1038/s41467-018-05074-y</a>
Alternative languages
Result language
angličtina
Original language name
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
Original language description
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications [online]
ISSN
2041-1723
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
August
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
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UT code for WoS article
000441381200005
EID of the result in the Scopus database
2-s2.0-85051632965