Do eyes with and without optic neuritis in multiple sclerosis age equally?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10378729" target="_blank" >RIV/00216208:11110/18:10378729 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/18:10378729

Result on the web

<a href="https://doi.org/10.2147/NDT.S169638" target="_blank" >https://doi.org/10.2147/NDT.S169638</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/NDT.S169638" target="_blank" >10.2147/NDT.S169638</a>

Result language

angličtina

Original language name

Do eyes with and without optic neuritis in multiple sclerosis age equally?

Original language description

Purpose: Anterior visual pathway reflects axonal loss caused by both optic neuritis (ON) and neurodegeneration in multiple sclerosis (MS). Although the axonal injury post-ON is thought to be complete by 6 months of onset, most studies using optical coherence tomography (OCT) to evaluate retinal changes as a marker of neurodegeneration exclude eyes with a history of ON or consider them separately. The objective of this study was to assess whether the eyes post-ON (&gt;6 months) show in later years different rate of chronic retinal changes than the fellow eyes not affected by ON. Patients and methods: Fifty-six patients with MS with a history of ON in one eye (ON eyes ) and no ON in the fellow (FL) eye, who were followed by OCT for &gt;2 years, were selected from a cohort of patients with MS. Paired eye analysis was performed. Results: Mean interval post-ON at baseline was 5.65 (SD 5.05) years. Mean length of follow-up by OCT was 4.57 years. There was no statistical difference in absolute or relative thinning of retinal nerve fiber layer in peripapillary area between the ON and FL eyes. Conclusion: This study has shown that we do not need to exclude eyes with a history of ON from longitudinal studies of neurodegeneration in MS, provided that we use data outside of the frame of acute changes post-ON. Long-term changes of peripapillary retinal nerve fiber layer in ON and FL eyes are equal.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropsychiatric Disease and Treatment

ISSN

1178-2021

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

September

Country of publishing house

NZ - NEW ZEALAND

Number of pages

5

Pages from-to

2281-2285

UT code for WoS article

000443749000001

EID of the result in the Scopus database

2-s2.0-85057529761