Modern and traditional approaches combined into an effective gray-box mathematical model of full-blood acid-base
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10380846" target="_blank" >RIV/00216208:11110/18:10380846 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/18:00327588
Result on the web
<a href="https://doi.org/10.1186/s12976-018-0086-9" target="_blank" >https://doi.org/10.1186/s12976-018-0086-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12976-018-0086-9" target="_blank" >10.1186/s12976-018-0086-9</a>
Alternative languages
Result language
angličtina
Original language name
Modern and traditional approaches combined into an effective gray-box mathematical model of full-blood acid-base
Original language description
Background: The acidity of human body fluids, expressed by the pH, is physiologically regulated in a narrow range, which is required for the proper function of cellular metabolism. Acid-base disorders are common especially in intensive care, and the acid-base status is one of the vital clinical signs for the patient management. Because acid-base balance is connected to many bodily processes and regulations, complex mathematical models are needed to get insight into the mixed disorders and to act accordingly. The goal of this study is to develop a full-blood acid-base model, designed to be further integrated into more complex human physiology models. Results: We have developed computationally simple and robust full-blood model, yet thorough enough to cover most of the common pathologies. Thanks to its simplicity and usage of Modelica language, it is suitable to be embedded within more elaborate systems. We achieved the simplification by a combination of behavioral Siggaard-Andersen's traditional approach for erythrocyte modeling and the mechanistic Stewart's physicochemical approach for plasma modeling. The resulting model is capable of providing variations in arterial pCO2, base excess, strong ion difference, hematocrit, plasma protein, phosphates and hemodilution/hemoconcentration, but insensitive to DPG and CO concentrations. Conclusions: This study presents a straightforward unification of Siggaard-Andersen's and Stewart's acid-base models. The resulting full-blood acid-base model is designed to be a core part of a complex dynamic whole-body acid base and gas transfer model.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30502 - Other medical science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Theoretical Biology and Medical Modelling
ISSN
1742-4682
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
14
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
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UT code for WoS article
000444533000001
EID of the result in the Scopus database
2-s2.0-85053126310