KDM2A/B lysine demethylases and their alternative isoforms in development and disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10381967" target="_blank" >RIV/00216208:11110/18:10381967 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1080/19491034.2018.1498707" target="_blank" >https://doi.org/10.1080/19491034.2018.1498707</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/19491034.2018.1498707" target="_blank" >10.1080/19491034.2018.1498707</a>
Alternative languages
Result language
angličtina
Original language name
KDM2A/B lysine demethylases and their alternative isoforms in development and disease
Original language description
Aberrant levels of histone modifications lead to chromatin malfunctioning and consequently to various developmental defects and human diseases. Therefore, the proteins bearing the ability to modify histones have been extensively studied and the molecular mechanisms of their action are now fairly well understood. However, little attention has been paid to naturally occurring alternative isoforms of chromatin modifying proteins and to their biological roles. In this review, we focus on mammalian KDM2A and KDM2B, the only two lysine demethylases whose genes have been described to produce also an alternative isoform lacking the N-terminal demethylase domain. These short KDM2A/B-SF isoforms arise through alternative promoter usage and seem to play important roles in development and disease. We hypothesise about the biological significance of these alternative isoforms, which might represent a more common evolutionarily conserved regulatory mechanism.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30106 - Anatomy and morphology (plant science to be 1.6)
Result continuities
Project
<a href="/en/project/GBP302%2F12%2FG157" target="_blank" >GBP302/12/G157: Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nucleus
ISSN
1949-1034
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
431-441
UT code for WoS article
000446713300001
EID of the result in the Scopus database
2-s2.0-85054777974