Insulin resistance is an underlying mechanism of impaired glucose metabolism during nilotinib therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10381977" target="_blank" >RIV/00216208:11110/18:10381977 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/18:00104917 RIV/61989592:15110/18:73587742 RIV/65269705:_____/18:00069062 RIV/00179906:_____/18:10381977 RIV/00023736:_____/18:00012020
Result on the web
<a href="https://doi.org/10.1002/ajh.25232" target="_blank" >https://doi.org/10.1002/ajh.25232</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ajh.25232" target="_blank" >10.1002/ajh.25232</a>
Alternative languages
Result language
angličtina
Original language name
Insulin resistance is an underlying mechanism of impaired glucose metabolism during nilotinib therapy
Original language description
Impaired glucose metabolism (IGM) with hyperglycemia represents one of the most frequently observed adverse events (AE) during nilotinib therapy of chronic myeloid leukemia (CML). The exact mechanism of IGM remains controversial. Although a case report has shown a decrease in insulin secretion, our previous pilot data suggested development of insulin resistance as a possible mechanism. In this prospective study we aimed to confirm results from our pilot study using a larger cohort of CML patients treated with nilotinib and to compare results with data obtained on control groups receiving imatinib and dasatinib.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NV17-30397A" target="_blank" >NV17-30397A: Mutational screening of primitive cell populations in chronic myeloid leukemia: BCR-ABL1 and beyond</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Hematology
ISSN
0361-8609
e-ISSN
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Volume of the periodical
93
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
"E342"-"E345"
UT code for WoS article
000447533300007
EID of the result in the Scopus database
2-s2.0-85052805148