MicroRNA expression in SMARCB1/INI1-deficient sinonasal carcinoma: a clinicopathological and molecular genetic study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10382292" target="_blank" >RIV/00216208:11110/18:10382292 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/18:10382292 RIV/61989592:15110/18:73590696 RIV/00179906:_____/18:10382292 RIV/00064165:_____/18:10382292
Result on the web
<a href="https://doi.org/10.1007/s00428-018-2293-5" target="_blank" >https://doi.org/10.1007/s00428-018-2293-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00428-018-2293-5" target="_blank" >10.1007/s00428-018-2293-5</a>
Alternative languages
Result language
angličtina
Original language name
MicroRNA expression in SMARCB1/INI1-deficient sinonasal carcinoma: a clinicopathological and molecular genetic study
Original language description
The aim of the study was to evaluate microRNA expression in SMARCB1/INI1-deficient sinonasal carcinomas by means of polymerase chain reaction. A total of 4/56 (7 %) cases of SMARCB1/INI1-deficient carcinomas were detected among 56 sinonasal carcinomas using immunohistochemical screening. The series comprised 3 males and 1 female, aged 27 - 76 years (median 64 years). All tumors arose in the nasal cavity. Three neoplasms were diagnosed in an advanced stage pT4. During the follow-up period (range 14 - 122 months (median 72 months)), three tumors recurred locally and two patients died due to the tumor. Microscopically, the tumors were composed of basaloid cells with variable component of rhabdoid cells with eosinophilic cytoplasm. All tumors showed upregulation of both miR-9 and miR-21 and downregulation of miR-145. In summary, we described four cases of SMARCB1/INI1-deficient sinonasal carcinoma with novel findings on microRNA expression, which might be important for new therapeutic strategies in the future.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Virchows Archiv
ISSN
0945-6317
e-ISSN
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Volume of the periodical
472
Issue of the periodical within the volume
5
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
871-875
UT code for WoS article
000433027400018
EID of the result in the Scopus database
2-s2.0-85040330733