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Real-world multiple myeloma management practice patterns and outcomes in selected Central and Eastern European countries

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10382753" target="_blank" >RIV/00216208:11110/18:10382753 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064165:_____/18:10382753

  • Result on the web

    <a href="https://doi.org/10.20452/pamw.4305" target="_blank" >https://doi.org/10.20452/pamw.4305</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.20452/pamw.4305" target="_blank" >10.20452/pamw.4305</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Real-world multiple myeloma management practice patterns and outcomes in selected Central and Eastern European countries

  • Original language description

    INTRODUCTION: Multiple myeloma (MM) treatment has evolved substantially in recent years. Solid data on the impact of treatment strategies on patient outcomes beyond clinical trials are scarce, especially in budget-restricted environments with limited access to new treatments. OBJECTIVES: This study investigated treatment practices, patterns, and outcomes in real-world clinical practice in Bulgaria, Croatia, Czech Republic, Poland, Romania, and Slovakia. PATIENTS AND METHODS: This was a noninterventional, observational chart review comprising a cross-sectional and a retrospective longitudinal phase observing adult patients with symptomatic MM at all stages of therapy. RESULTS: The study revealed structural differences in clinical practice compared with a similarly designed study previously conducted in 7 Western European countries. Stem cell transplantation was performed in less than half of newly diagnosed eligible patients. The most frequently used first-line regimens were bortezomib based, with frequent bortezomib retreatment after the first relapse. Lenalidomide-based regimens were predominant in the third and subsequent lines of therapy. Depth of response decreased with each treatment line, with half of patients achieving at least very good partial response (&gt;= VGPR) in the first line, while only one-fourth achieved &gt;= VGPR in the third or subsequent lines. Time to progression was longer in patients with better response levels. CONCLUSIONS: Inadequate access to advanced antimyeloma regimens and-in some countries-stem cell transplantation highlights the challenges of MM treatment in the region. Information on real-world patient management and its outcomes can provide valuable input for decision makers to effectively allocate limited resources.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Polskie Archiwum Medycyny Wewnetrznej

  • ISSN

    0032-3772

  • e-ISSN

  • Volume of the periodical

    128

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    PL - POLAND

  • Number of pages

    12

  • Pages from-to

    500-511

  • UT code for WoS article

    000448876300003

  • EID of the result in the Scopus database

    2-s2.0-85054338703