Oropharyngeal surfactant can improve initial stabilisation and reduce rescue intubation in infants born below 25weeks of gestation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10385383" target="_blank" >RIV/00216208:11110/18:10385383 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/18:10385383

Result on the web

<a href="https://doi.org/10.1111/apa.14060" target="_blank" >https://doi.org/10.1111/apa.14060</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/apa.14060" target="_blank" >10.1111/apa.14060</a>

Result language

angličtina

Original language name

Oropharyngeal surfactant can improve initial stabilisation and reduce rescue intubation in infants born below 25weeks of gestation

Original language description

Aim: Minimally aggressive and easily performed techniques that facilitate spontaneous respiratory stabilisation are required to reduce rescue intubation in extremely premature infants. This study evaluated the feasibility and safety of administering surfactant into the pharynx of infants born at &lt;25weeks immediately after birth. Methods: This study of 19 infants was conducted from January 2013 to June 2014 in a tertiary perinatal centre in Prague. We administered 1.5mL of Curosurf as a bolus into the pharynx and simultaneously performed a sustained inflation manoeuvre (SIM). The extent of the interventions, death and severe neonatal morbidity in the study group were compared with 20 controls born before the study period and 20 born after it. Results: All infants received oropharyngeal surfactant within the median (interquartile range) time of 40seconds (25-75) after cord camping. The surfactant had to be suctioned in one infant because of upper airway obstruction. Although more subsequent surfactant was administered in the study group, significantly fewer study period infants required intubation than the before and after controls (16% versus 75% and 58%, respectively, p&lt;0.01). Conclusion: Oropharyngeal surfactant with simultaneous SIM was feasible and safe and reduced the need for delivery room intubation in these fragile infants.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

O - Projekt operacniho programu

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Paediatrica

ISSN

0803-5253

e-ISSN

—

Volume of the periodical

107

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

73-78

UT code for WoS article

000417865400014

EID of the result in the Scopus database

2-s2.0-85037747847