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Surgical treatment of "intermediate risk" lymph node negative cervical cancer patients without adjuvant radiotherapy-A retrospective cohort study and review of the literature

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10388413" target="_blank" >RIV/00216208:11110/18:10388413 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/18:00104966 RIV/00064165:_____/18:10388413

  • Result on the web

    <a href="https://doi.org/10.1016/j.ygyno.2018.10.018" target="_blank" >https://doi.org/10.1016/j.ygyno.2018.10.018</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ygyno.2018.10.018" target="_blank" >10.1016/j.ygyno.2018.10.018</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Surgical treatment of "intermediate risk" lymph node negative cervical cancer patients without adjuvant radiotherapy-A retrospective cohort study and review of the literature

  • Original language description

    Objectives. The role of adjuvant radiotherapy for lymph node-negative stage IB patients with tumor-related negative prognostic factors is not uniformly accepted. It is advocated based on the GOG 92 trial, which was initiated in 1989. The aim of the current study is to report the oncological outcome of &quot;intermediate risk&quot; patients treated by tailored surgery without adjuvant radiotherapy. Data from two institutions that refer these patients for adjuvant radiotherapy served as a control group. Methods. Included were patients with stage IB cervical cancer treated with radical hysterectomy and pelvic lymphadenectomy, who had negative pelvic lymph nodes but a combination of negative prognostic factors adopted from the GOG 92 trial. Data were obtained from prospectively collected databases of three institutions. Radical surgery was a single-treatment modality in one of them and in the remaining two institutes it was followed by adjuvant chemoradiation. Results. In 127 patients who received only radical surgery, with a median follow-up of 6.1 years, the local recurrence rate was 1.6% (2 cases), and total recurrence was 6.3% (8 cases). Disease-specific survival at 5 years was 95.7% (91.9%: 99.4%) and 91% (83.7%; 98.3%) at 10 years. The only significant factor for disease-specific survival was tumor size &gt;= 4 cm (P = 0.032). The recurrence rate, local control or overall survival did not differ from the control group. Adjuvant radiotherapy was not a significant prognostic factor within the whole cohort. Conclusions. An excellent oncological outcome, especially local control, can be achieved by both radical surgery or combined treatment in stage IB lymph node-negative cervical cancer patients with negative prognostic factors. The substantially better outcome than in the GOG 92 trial can be attributed to more accurate pre-operative and pathological staging and an improvement in surgical techniques.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30214 - Obstetrics and gynaecology

Result continuities

  • Project

    <a href="/en/project/NV16-31643A" target="_blank" >NV16-31643A: Sentinel lymph node biopsy versus systematic pelvic lymphadenectomy in patients with early stages cervical cancer</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Gynecologic Oncology

  • ISSN

    0090-8258

  • e-ISSN

  • Volume of the periodical

    151

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    438-443

  • UT code for WoS article

    000456637800009

  • EID of the result in the Scopus database

    2-s2.0-85055134300