Predictors of oropharyngeal cancer survival in Europe
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10391907" target="_blank" >RIV/00216208:11110/18:10391907 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.oraloncology.2018.04.016" target="_blank" >https://doi.org/10.1016/j.oraloncology.2018.04.016</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.oraloncology.2018.04.016" target="_blank" >10.1016/j.oraloncology.2018.04.016</a>
Alternative languages
Result language
angličtina
Original language name
Predictors of oropharyngeal cancer survival in Europe
Original language description
Objectives: HPV16-positive oropharyngeal cancer (OPC) patients experience better outcomes compared to HPV16-negative patients. Currently, strategies for treatment de-escalation are based on HPV status, smoking history and disease stage. However, the appropriate cut-point for smoking and the role of other non-clinical factors in OPC survival remains uncertain. Materials and Methods: We examined factors associated with OPC outcome in 321 patients recruited in a large European multi-center study. Seropositivity for HPV16 E6 was used as a marker of HPV16 positive cancer. Hazard ratios (HR) and confidence intervals (CI) were estimated using Cox proportional models adjusted for potential confounders. Results: Overall 5-year survival following OPC diagnosis was 50%. HPV16-positive OPC cases were at significantly lower risk of death (aHR = 0.51, 95% CI: 0.32-0.80). A significant effect on OPC survival was apparent for female sex (aHR 0.50: 95% CI: 0.29-0.85) and being underweight at diagnosis (aHR: 2.41, 95% CI: 1.38-4.21). A 10 pack year smoking history was not associated with overall survival. Higher stage at diagnosis appeared as the only factor significantly associated with OPC recurrence (aHR: 4.88, 95% CI: 2.12-11.21). Conclusion: This study confirms that HPV16 status is an independent prognostic factor for OPC survival while female sex lowers risk of death and being underweight at diagnosis increases the risk of death. Smoking was not an independent predictor of OPC survival.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oral Oncology
ISSN
1368-8375
e-ISSN
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Volume of the periodical
81
Issue of the periodical within the volume
June
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
89-94
UT code for WoS article
000434682200013
EID of the result in the Scopus database
2-s2.0-85046774488