Pentamethinium salts as ligands for cancer: Sulfated polysaccharide co-receptors as possible therapeutic target
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F19%3A10396078" target="_blank" >RIV/00216208:11110/19:10396078 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/19:73598856 RIV/60461373:22330/19:43917415 RIV/60461373:22340/19:43917415 RIV/68378050:_____/19:00538135
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NY~5mO215H" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NY~5mO215H</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bioorg.2018.02.011" target="_blank" >10.1016/j.bioorg.2018.02.011</a>
Alternative languages
Result language
angličtina
Original language name
Pentamethinium salts as ligands for cancer: Sulfated polysaccharide co-receptors as possible therapeutic target
Original language description
A series of pentamethinium salts with benzothiazolium and indolium side units comprising one or two positive charges were designed and synthesized to determine the relationships among the molecular structure, charge density, affinity to sulfated polysaccharides, and biological activity. Firstly, it was found that the affinity of the pentamethinium salts to sulfated polysaccharides correlated with their biological activity. Secondly, the side heteroaromates displayed a strong effect on the cytotoxicity and selectivity towards cancer cells. Finally, doubly charged pentamethinium salts possessing benzothiazolium side units exhibited remarkably high efficacy against a taxol-resistant cancer cell line.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic Chemistry
ISSN
0045-2068
e-ISSN
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Volume of the periodical
82
Issue of the periodical within the volume
February
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
74-85
UT code for WoS article
000455479600009
EID of the result in the Scopus database
2-s2.0-85054021008