Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F19%3A10399721" target="_blank" >RIV/00216208:11110/19:10399721 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=plcqj8._Cq" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=plcqj8._Cq</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.oraloncology.2019.05.006" target="_blank" >10.1016/j.oraloncology.2019.05.006</a>
Alternative languages
Result language
angličtina
Original language name
Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach
Original language description
Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) > 5 was reached after 30 years in current smokers of similar to 20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs > 20 were found for current smokers of >= 20 cigarettes/day for >= 30 years. In former smokers who quit >= 10 years ago, the ORs were approximately halved for OCP cancers, and similar to 1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oral Oncology
ISSN
1368-8375
e-ISSN
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Volume of the periodical
94
Issue of the periodical within the volume
July
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
47-57
UT code for WoS article
000470244300008
EID of the result in the Scopus database
2-s2.0-85065698410