Bilirubin as a predictor of diseases of civilization. Is it time to establish decision limits for serum bilirubin concentrations?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F19%3A10409950" target="_blank" >RIV/00216208:11110/19:10409950 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=W4Rs__euTl" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=W4Rs__euTl</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.abb.2019.108062" target="_blank" >10.1016/j.abb.2019.108062</a>
Alternative languages
Result language
angličtina
Original language name
Bilirubin as a predictor of diseases of civilization. Is it time to establish decision limits for serum bilirubin concentrations?
Original language description
Bilirubin is among the most potent of the endogenous antioxidants. Data developed over the last three decades have convincingly demonstrated the protective effects of mildly elevated serum bilirubin concentrations; whereas lower levels of it have been associated with an increased risk of various diseases of civilization, commonly accompanied with increased oxidative stress. Even tiny, micromolar changes of serum bilirubin concentrations have been associated with substantial modulation for the risk of these diseases. However, clinical data published in the current literature are influenced by many confounding factors that have not been properly controlled for. These include the use of improper reference intervals, which are mostly used as common intervals without any partitioning for gender, ethnicity, age, or other important factors (such as smoking). The clinical chemistry methods used for bilirubin determination have not been standardized; in fact, these methods are known to be among the least reliable of any used in clinical chemistry labs. As a result, the data from epidemiological studies are not always comparable. Therefore, it is highly recommended to conduct properly-designed large epidemiological studies. Based on this data, the establishment of decision limits is highly warranted, especially for the lower concentration values of serum bilirubin.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/NV16-27317A" target="_blank" >NV16-27317A: Induction of hyperbilirubinemia by plant flavonolignans as a new tool for the prevention of increased oxidative stress</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of Biochemistry and Biophysics
ISSN
0003-9861
e-ISSN
—
Volume of the periodical
672
Issue of the periodical within the volume
September
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
108062
UT code for WoS article
000525439000011
EID of the result in the Scopus database
2-s2.0-85071783414