Case Study: Methanol mass poisoning outbreak in the Czech Republic: Diagnosis, treatment and outcome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F19%3A10410716" target="_blank" >RIV/00216208:11110/19:10410716 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/19:10410716
Result on the web
<a href="http://dx.doi.org/10.1039/9781782623687-00263" target="_blank" >http://dx.doi.org/10.1039/9781782623687-00263</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/9781782623687-00263" target="_blank" >10.1039/9781782623687-00263</a>
Alternative languages
Result language
angličtina
Original language name
Case Study: Methanol mass poisoning outbreak in the Czech Republic: Diagnosis, treatment and outcome
Original language description
Methanol outbreaks are a global public health issue, with poor outcomes associated with delayed treatment. We report the data from the mass methanol poisoning outbreak in the Czech Republic in 2012-2014. From a total of 137 poisoned subjects, 31 died outside the hospital and 106 were hospitalized. Of these, 83 patients survived. The total and hospital mortality rates were 39% and 22%, respectively. Arterial blood pH under 7.0, negative serum ethanol and coma on admission were the independent parameters predicting death. We found a positive association between out-of-hospital ethanol administration and improved treatment outcome. Both antidotes, fomepizole and ethanol, may be considered for alcohol dehydrogenase blockade in hospital without limitations. Intermittent haemodialysis is superior to continuous modalities in terms of the rate of elimination of both methanol and formate. The prevalence of long-term visual sequelae after methanol poisoning was significantly higher than the prevalence of visual disturbances at the time of discharge from hospital. Altogether, 40% of examined survivors had abnormal morphological and functional findings complying with the criteria of long-term visual damage 3-8 months after discharge. The prevalence of long-term central nervous system sequelae was clearly underestimated at discharge from hospital, as magnetic resonance examination revealed brain lesions in 52% of the survivors.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Chemical Health Threats: Assessing and Alerting
ISBN
978-1-78262-071-6
Number of pages of the result
8
Pages from-to
263-270
Number of pages of the book
309
Publisher name
The Royal Society of Chemistry
Place of publication
London
UT code for WoS chapter
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