Mummified cells are a common finding in cutaneous Hodgkin lymphoma and can be used as a diagnostic clue
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10402178" target="_blank" >RIV/00216208:11110/20:10402178 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/20:10402178 RIV/00669806:_____/20:10402178 RIV/00064165:_____/20:10402178
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=n.DMKC_iQ0" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=n.DMKC_iQ0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/DAD.0000000000001445" target="_blank" >10.1097/DAD.0000000000001445</a>
Alternative languages
Result language
angličtina
Original language name
Mummified cells are a common finding in cutaneous Hodgkin lymphoma and can be used as a diagnostic clue
Original language description
Specific cutaneous involvement in Hodgkin lymphoma israre. In cutaneous lesions, the diagnosis is usually based on therecognition of diagnostic Reed-Sternberg cells and its variants. Innodal Hodgkin lymphoma, so-called mummified cells (cells with con-densed cytoplasm and pyknotic eosinophilic or basophilic nuclei) areoften seen. They are sometimes conspicuous and easy to recognize,thus serving as a clue to the diagnosis. Our objective was to studycases of cutaneous Hodgkin lymphoma to identify the occurrence ofmummified cells. We studied 12 patients (4 women and 8 men; agerange 23-80 years). In 6 patients, cutaneous and extracutaneous dis-ease was identified almost simultaneously; in 4 patients, lymph nodedisease preceded cutaneous involvement; and in the remaining 2 pa-tients, the skin lesions were the presenting sign, whereas lymph nodeinvolvement occurred later. Histopathological, immunohistochemical,and molecular-genetic studies, including rearrangements for TCR, IgHgenes, and PCR for EBV, were performed. Cutaneous biopsy speci-mens revealed either a multinodular or diffuse infiltrate, includedsmall lymphocytes, eosinophils, plasma cells, and macrophages, butin all cases, diagnostic Reed-Sternberg cells and its variants wereidentified. Mummified cells were detected in 9 cases, either as occa-sional scattered mummified cells often requiring a search (6 cases) orbeing conspicuous, grouped and therefore easily identified (3 cases).Immunohistochemically, in all 7 cases studied, mummified cells werepositive for both CD30 and CD15. It is concluded that mummifiedcells are encountered in a majority of cases of cutaneous Hodgkinlymphoma.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The American Journal of Dermatopathology
ISSN
0193-1091
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
24-28
UT code for WoS article
000524344700011
EID of the result in the Scopus database
2-s2.0-85077294845