Rapidly progressing acute myeloid leukemia with KAT6A-LEUTX fusion in a newborn

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10413227" target="_blank" >RIV/00216208:11110/20:10413227 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/20:10413227 RIV/00064203:_____/20:10413227 RIV/00064165:_____/20:10413227
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=mDzSFYk8NU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=mDzSFYk8NU</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/pbc.28663" target="_blank" >10.1002/pbc.28663</a>

Result language
angličtina
Original language name
Rapidly progressing acute myeloid leukemia with KAT6A-LEUTX fusion in a newborn
Original language description
We believe that the KAT6-LEUTX fusion is a very rare, yet recurrent fusion in AML, potentially more frequent in infants and among treatment-related AML, similar to KAT6-CREBBP (and KMT2Ar AML). Although acute myeloid leukemias in infants with other KAT6A fusions (KAT6A-CREBBP, KAT6A-EP300) are associated with a considerable chance of spontaneous remission, we observed an extremely aggressive course of the disease in a neonate with the biologically related KAT6A-LEUTX fusion. This case demonstrates how complicated clinical decisions are in cAML, where we are unable to predict the course of the disease regardless of progress in molecular diagnostics and classification.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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