Methylene blue administration in patients with refractory distributive shock - a retrospective study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10413913" target="_blank" >RIV/00216208:11110/20:10413913 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/20:10413913
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WR-TzgjXrJ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WR-TzgjXrJ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-020-58828-4" target="_blank" >10.1038/s41598-020-58828-4</a>
Alternative languages
Result language
angličtina
Original language name
Methylene blue administration in patients with refractory distributive shock - a retrospective study
Original language description
Hemodynamic effectiveness of methylene blue (MB) was tested in patients with refractory distributive shock. A retrospective analysis of 20 critically-ill patients who developed refractory shock was performed. Patients were divided into two study groups as responders with positive hemodynamic response to MB administration (defined as 10% decrease of norepinephrine dose) and non-responders. Hemodynamic, outcome data and baseline tissue hypoxia-related parameters including ratio of central venous-to-arterial carbon dioxide tension to arterio-venous oxygen content (P(v-a)CO2/C(a-v)O-2) were compared between the groups. There were 9 (45%) responders and 11 (55%) non-responders to single bolus of MB administration. Dose of MB did not differ between responders and non-responders (1.3 +/- 0.5 vs. 1.3 +/- 0.4mg/kg respectively, P=0.979). MB responders had lower baseline P(v-a) CO2/C(a-v)O-2 (1.79 +/- 0.73 vs. 3.24 +/- 1.18, P=0.007), higher pH (7.26 +/- 0.11 vs. 7.16 +/- 0.10, P=0.037) and lower lactate levels at 12hours post MB administration (3.4 +/- 2.7 vs. 9.9 +/- 2.2mmol/L, P=0.002) compared to non-responders. Methylene blue represents a non-adrenergic vasopressor with only limited effectiveness in patients with refractory distributive shock. Profound tissue hypoxia with high degree of anaerobic metabolism was associated with the loss of hemodynamic responsiveness to its administration.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30223 - Anaesthesiology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
1828
UT code for WoS article
000559933700001
EID of the result in the Scopus database
2-s2.0-85078987294