Serum Bilirubin in the Czech Population - Relationship to the Risk of Myocardial Infarction in Males

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10416315" target="_blank" >RIV/00216208:11110/20:10416315 - isvavai.cz</a>

Alternative codes found

RIV/00064190:_____/20:N0000038 RIV/00023001:_____/20:00080273 RIV/00064165:_____/20:10416315

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=pXvnKMu9q1" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=pXvnKMu9q1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1253/circj.CJ-20-0192" target="_blank" >10.1253/circj.CJ-20-0192</a>

Result language

angličtina

Original language name

Serum Bilirubin in the Czech Population - Relationship to the Risk of Myocardial Infarction in Males

Original language description

Background: The potential antiatherogenic role of bilirubin is generally acknowledged, so the aim of this study was to determine serum bilirubin concentrations and the prevalence of Gilbert syndrome (GS) in the Czech general population with particular reference to its relationship to the risk of myocardial infarction (MI). Methods and Results: Biochemical markers were analyzed in 2 independent Czech post-MONICA studies (in total, n=3,311), and in 741 male MI patients. The UGT1A1 promoter gene variant (rs81753472) was analyzed in these MI patients and in the first control population cohort (n=717). Medians of serum bilirubin concentrations in the 2 Czech general population cohorts were 9.6 and 9.8 mu mol/L (10.7 and 11.3 mu mol/L in males, and 8.3 and 8.8 mu mol/L in females; P&lt;0.01). The prevalence of GS was 8.9%, twice as high in males compared with females (11.6 vs. 6.1%; P&lt;0.01). The UGT1A1 (TA) 7/7 promoter repeats significantly influenced serum bilirubin concentrations in the controls, but not in the MI patients. Serum bilirubin concentrations were significantly lower in MI patients (7.7 vs. 10.7 mu mol/L; P&lt;0.01), with almost 5-fold lower prevalence of GS. Conclusions: Serum bilirubin concentrations and the prevalence of GS were determined in the Czech general population. Significantly lower serum bilirubin concentrations were observed in male MI patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Circulation Journal

ISSN

1346-9843

e-ISSN

—

Volume of the periodical

84

Issue of the periodical within the volume

10

Country of publishing house

JP - JAPAN

Number of pages

7

Pages from-to

1779-1785

UT code for WoS article

000575438200016

EID of the result in the Scopus database

2-s2.0-85091807701