Modified forearm ischemic test in hypouricemic patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10418520" target="_blank" >RIV/00216208:11110/20:10418520 - isvavai.cz</a>
Alternative codes found
RIV/00023728:_____/20:N0000048
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ZO_upWxQYl" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ZO_upWxQYl</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15257770.2020.1750636" target="_blank" >10.1080/15257770.2020.1750636</a>
Alternative languages
Result language
angličtina
Original language name
Modified forearm ischemic test in hypouricemic patients
Original language description
Renal hypouricemia sometimes leads to exercise-induced acute kidney injury (EIAKI) of unknown pathogenesis. In order to elucidate the various pathological conditions associated with hypouricemia, we analyzed the effects of low uric acid level on energy metabolism. We have modified semi-ischemic forearm exercise test and performed this test in one Japanese healthy volunteer, three patients with hereditary renal hypouricemia and one patient with hereditary xanthinuria of Czech origin. Forearm exercise was performed by squeezing a hand dynamometer with the sphygmomanometer cuff pressure kept at the mean arterial pressure. Venous blood was drawn five times (before exercise, 3, 10, 30, 45 minutes after the start of exercise) in each tests. The mean plasma lactate concentration increased from a baseline of 1.3 (range 0.7-1.8 mmol/L) to 4.0 (range 2.0-5.5 mmol/L) at 3 minutes after the start of exercise. The plasma hypoxanthine concentrations were quite low before exercise (0-2.9 mu mol/L), but increased markedly to a range of 13.6-28.8 mu mol/L after 10 minute forearm ischemia. Our protocol allowed us to conclude that the load was sufficient for observing metabolic changes in temporally hypoxia and in following recovery phase. The test was well tolerated and safe, we did not observe any adverse reactions including EIAKI.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770
e-ISSN
—
Volume of the periodical
39
Issue of the periodical within the volume
10-12
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1432-1439
UT code for WoS article
000527583400001
EID of the result in the Scopus database
2-s2.0-85083719428