Clinical characteristics of newly diagnosed Parkinson's disease patients included in the longitudinal BIO-PD study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10422399" target="_blank" >RIV/00216208:11110/20:10422399 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/20:10422399

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_mT2CS1Uc9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_mT2CS1Uc9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccsnn2020633" target="_blank" >10.48095/cccsnn2020633</a>

Result language

angličtina

Original language name

Clinical characteristics of newly diagnosed Parkinson's disease patients included in the longitudinal BIO-PD study

Original language description

Aim: The aim of this study was to describe the protocol of the longitudinal observational study &quot;Biomarkers of Parkinson&apos;s disease&quot; (BIO-PD) and provide clinical characteristics of newly diagnosed Parkinson&apos;s disease (PD) patients enrolled in the BIO-PD study to date. Methods: Treatment-naive PD patients diagnosed according to the Movement Disorders Society clinical diagnostic criteria with abnormal finding on dopamine transporter SPECT as well as healthy controls were enrolled in the study. Baseline examination included brain MRI, structured interview, Movement Disorders Society-Unified PD Rating Scale (MDS-UPDRS), video-polysomnography, transcranial sonography, olfactory testing, visual color sensitivity, a battery of neurophysiological tests, detailed cognitive testing, a comprehensive set of questionnaires as well as sampling of biofluids. Results: As of July 2020, 95 PD patients (37 females, mean age 61.0 [SD = 12.4] years, mean symptom duration 1.9 [1.7] years) and 57 healthy controls (15 females, mean age 62.2 [9.4] years) were included in the study. Compared to controls, PD patients were more likely to be never smokers (P = 0.02) and to have a history of anxiety or depression disorder (P = 0.02), and constipation (P = 0.002). In addition, PD patients had worse scores in the visual color sensitivity (Farnsworth-Munsell Hue 100) test (P = 0.002), MDS-UPDRS motor score, Beck depression inventory-II, State-Trait Anxiety Inventory X1/ X2, Scales for Outcomes in PD-Autonomic questionnaire (SCOPA-AUT), University of Pennsylvania Smell Identification Test, and more frequent substantia nigra hyperechogenicity on transcranial sonography (P &lt; 0.001 for all tests). The frequencies of symptoms and abnormal findings in PD patients were as follows: hyposmia 82.4%, substantia nigra hyperechogenicity 75.4%, history of anxiety or depression disorder 29.5%, constipation 22.1%, and REM (rapid eye movement) sleep behavior disorder 22%. Conclusion: Baseline characteristics of patients enrolled in the BIO-PD study are comparable to other de novo PD cohorts, indicating that it is a representative sample of PD patients. Hyposmia is the most prevalent non-motor abnormality in newly diagnosed PD patients and is thus a suitable diagnostic marker for early PD

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NV15-25602A" target="_blank" >NV15-25602A: Biomarkers of progression and treatment response in neurodegenerative disorders</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

—

Volume of the periodical

83

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

633-639

UT code for WoS article

000645469800001

EID of the result in the Scopus database

2-s2.0-85099960069