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Pre-school and school-aged children benefit from the switch from a sensor-augmented pump to an AndroidAPS hybrid closed loop: A retrospective analysis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10423103" target="_blank" >RIV/00216208:11110/21:10423103 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064203:_____/21:10423103 RIV/00216208:11130/21:10423103

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=aN9hO--HE9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=aN9hO--HE9</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/pedi.13190" target="_blank" >10.1111/pedi.13190</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Pre-school and school-aged children benefit from the switch from a sensor-augmented pump to an AndroidAPS hybrid closed loop: A retrospective analysis

  • Original language description

    Data on closed loop systems in young children with type 1 diabetes (T1D) are limited. We tested the efficacy and safety of an open-source, do-it-yourself automated insulin delivery system AndroidAPS in preschool and school-aged children. Research Design and Methods: This retrospective study analyzed diabetes control in 18 preschool (3-7 years) and 18 school-aged children (8-14 years) with T1D who switched from a sensor-augmented pump (SAP) to AndroidAPS. We compared the CGM parameters and HbA1c levels 3 months before and 6 months after the initiation of AndroidAPS therapy and evaluated frequency of severe adverse events during AndroidAPS use, the most frequent reasons for its interruption, and the experience and psychosocial benefits of AndroidAPS use. General glycemic control was significantly improved after the switch from SAP to AndroidAPS. Time in range (TIR) increased in both preschool (70.8 to 78.6%, p = 0.004) and school-aged children (77.2 to 82.9%, p &lt; 0.001), whereas HbA1c levels decreased (preschool children 53.8 to 48.5 mmol/mol, p &lt; 0.001; school-aged children 52.6 to 45.1 mmol/mol, p = 0.001). Time spent in range of 3.0-3.8 mmol/L increased slightly in school children (2.6 to 3.8%, p = 0.040), but not in preschool children (3.0 to 3.0%, p = 0.913). Time spent at &lt;3 mmol/L remained unchanged in both preschool (0.95 to 0.67%, p = 0.432) and school-aged children (0.8 to 0.8%, p = 1.000). No episodes of severe hypoglycemia or DKA and significant improvement of quality of life were reported by AndroidAPS users. AndroidAPS seems effective for T1D control both in preschool and school-age children but further validation by prospective studies is necessary.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pediatric Diabetes

  • ISSN

    1399-543X

  • e-ISSN

  • Volume of the periodical

    22

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    594-604

  • UT code for WoS article

    000621585600001

  • EID of the result in the Scopus database

    2-s2.0-85101645931