Pre-school and school-aged children benefit from the switch from a sensor-augmented pump to an AndroidAPS hybrid closed loop: A retrospective analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10423103" target="_blank" >RIV/00216208:11110/21:10423103 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/21:10423103 RIV/00216208:11130/21:10423103
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=aN9hO--HE9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=aN9hO--HE9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/pedi.13190" target="_blank" >10.1111/pedi.13190</a>
Alternative languages
Result language
angličtina
Original language name
Pre-school and school-aged children benefit from the switch from a sensor-augmented pump to an AndroidAPS hybrid closed loop: A retrospective analysis
Original language description
Data on closed loop systems in young children with type 1 diabetes (T1D) are limited. We tested the efficacy and safety of an open-source, do-it-yourself automated insulin delivery system AndroidAPS in preschool and school-aged children. Research Design and Methods: This retrospective study analyzed diabetes control in 18 preschool (3-7 years) and 18 school-aged children (8-14 years) with T1D who switched from a sensor-augmented pump (SAP) to AndroidAPS. We compared the CGM parameters and HbA1c levels 3 months before and 6 months after the initiation of AndroidAPS therapy and evaluated frequency of severe adverse events during AndroidAPS use, the most frequent reasons for its interruption, and the experience and psychosocial benefits of AndroidAPS use. General glycemic control was significantly improved after the switch from SAP to AndroidAPS. Time in range (TIR) increased in both preschool (70.8 to 78.6%, p = 0.004) and school-aged children (77.2 to 82.9%, p < 0.001), whereas HbA1c levels decreased (preschool children 53.8 to 48.5 mmol/mol, p < 0.001; school-aged children 52.6 to 45.1 mmol/mol, p = 0.001). Time spent in range of 3.0-3.8 mmol/L increased slightly in school children (2.6 to 3.8%, p = 0.040), but not in preschool children (3.0 to 3.0%, p = 0.913). Time spent at <3 mmol/L remained unchanged in both preschool (0.95 to 0.67%, p = 0.432) and school-aged children (0.8 to 0.8%, p = 1.000). No episodes of severe hypoglycemia or DKA and significant improvement of quality of life were reported by AndroidAPS users. AndroidAPS seems effective for T1D control both in preschool and school-age children but further validation by prospective studies is necessary.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatric Diabetes
ISSN
1399-543X
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
594-604
UT code for WoS article
000621585600001
EID of the result in the Scopus database
2-s2.0-85101645931