Mitochondrial Kinases and the Role of Mitochondrial Protein Phosphorylation in Health and Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10427835" target="_blank" >RIV/00216208:11110/21:10427835 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vTStxyLDgp" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vTStxyLDgp</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/life11020082" target="_blank" >10.3390/life11020082</a>
Alternative languages
Result language
angličtina
Original language name
Mitochondrial Kinases and the Role of Mitochondrial Protein Phosphorylation in Health and Disease
Original language description
The major role of mitochondria is to provide cells with energy, but no less important are their roles in responding to various stress factors and the metabolic changes and pathological processes that might occur inside and outside the cells. The post-translational modification of proteins is a fast and efficient way for cells to adapt to ever changing conditions. Phosphorylation is a post-translational modification that signals these changes and propagates these signals throughout the whole cell, but it also changes the structure, function and interaction of individual proteins. In this review, we summarize the influence of kinases, the proteins responsible for phosphorylation, on mitochondrial biogenesis under various cellular conditions. We focus on their role in keeping mitochondria fully functional in healthy cells and also on the changes in mitochondrial structure and function that occur in pathological processes arising from the phosphorylation of mitochondrial proteins.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
<a href="/en/project/GJ18-25144Y" target="_blank" >GJ18-25144Y: Structural exploration of the ATP-dependent human mitochondrial Lon protease for drug design and further understanding of its mechanism of action</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Life [online]
ISSN
2075-1729
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
37
Pages from-to
82
UT code for WoS article
000622743800001
EID of the result in the Scopus database
2-s2.0-85099853794