Validation Study of a German Cognitive Battery for Huntington's Disease: Relationship Between Cognitive Performance, Functional Decline, and Disease Burden

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10428770" target="_blank" >RIV/00216208:11110/21:10428770 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/21:10428770

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yDsY5OxCXA" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yDsY5OxCXA</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/arclin/acaa038" target="_blank" >10.1093/arclin/acaa038</a>

Result language

angličtina

Original language name

Validation Study of a German Cognitive Battery for Huntington's Disease: Relationship Between Cognitive Performance, Functional Decline, and Disease Burden

Original language description

Objective: Cognitive decline is a key characteristic of Huntington&apos;s disease (HD). This study aimed to investigate the diagnostic accuracy of a cognitive battery with six tests used by most HD research centers to assess cognitive impairment in HD. Method: In total, 106 HD patients in different disease stages with more (HD-CD, N = 30) and less cognitive impairments (HD-NC, N = 70) and 100 healthy controls (NC) were matched by age, sex, and education and were examined using a standardized protocol including cognitive, motor, and functional assessments. Results: One-way between-groups analysis of variance showed that controls performed significantly better than HD patients and that HD-NC significantly outperformed HD-CD patients in all cognitive tests (NC &gt; HD-NC &gt; HD-CD), with all Games-Howell post-hoc tests p &lt; .001. Analyses using area under the receiver-operating characteristic curve (AUC) disclosed the diagnostic accuracy of all tests included in the battery to discriminate between NC and HD patients with AUC ranging from 0.809 to 0.862 (all p &lt; .001) and between HD-CD and HD-NC patients with AUC ranging from 0.833 to 0.899 (all p &lt; .001). In both analysis, Stroop Color Naming Test showed the highest discriminative potential. Additional analyses showed that cognitive deficits in all domains progressed with disease duration. Moreover, cognitive performance correlated with the severity of motor and functional impairment (all p &lt; .001) and with the Disease Burden Score regardless of disease duration and age. Conclusion: Our results indicate that the cognitive battery is a suitable tool for assessing cognitive impairment in HD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of Clinical Neuropsychology

ISSN

0887-6177

e-ISSN

—

Volume of the periodical

36

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

74-86

UT code for WoS article

000649437300007

EID of the result in the Scopus database

2-s2.0-85100070017