Effect of adrenalectomy on remission of subclinical left ventricular dysfunction in patients with pheochromocytoma: a speckle-tracking echocardiography study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10434891" target="_blank" >RIV/00216208:11110/21:10434891 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/21:10434891
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=xos5..ij-C" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=xos5..ij-C</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1530/EC-21-0462" target="_blank" >10.1530/EC-21-0462</a>
Alternative languages
Result language
angličtina
Original language name
Effect of adrenalectomy on remission of subclinical left ventricular dysfunction in patients with pheochromocytoma: a speckle-tracking echocardiography study
Original language description
Background: Pheochromocytomas (PHEO) are tumours with the ability to produce, metabolize and secrete catecholamines. Catecholamines overproduction leads to the decrease of longitudinal function of the left ventricle (LV) measured by speckle-tracking echocardiography. Patients with PHEO have a lower magnitude of global longitudinal strain (GLS) than patients with essential hypertension. GLS normalization is expected after resolution of catecholamine overproduction. Methods: Twenty-four patients (14 females and 10 males) with a recent diagnosis of PHEO have been examined before and 1 year after adrenalectomy. An echocardiographic examination including speckle-tracking analysis with the evaluation of GLS and regional longitudinal strain (LS) in defined groups of LV segments (basal, mid-ventricular and apical) was performed. Results: One year after adrenalectomy, the magnitude of GLS increased (-14.3 +- 1.8 to -17.7 +- 1.6%; P < 0.001). When evaluating the regional LS, the most significant increase in the differences was evident in the apical segment compared to mid-ventricular and basal segments of LV (-5.4 +- 5.0 vs -1.9 +- 2.7 vs -1.6 +- 3.8; P < 0.01). Conclusions: In patients with PHEO, adrenalectomy leads to an improvement of subclinical LV dysfunction represented by the increasing magnitude of GLS, which is the most noticeable in apical segments of LV.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
<a href="/en/project/NV19-01-00083" target="_blank" >NV19-01-00083: IDENTIFICATION OF CRITICAL PROTEINS AND MOLECULAR PATHWAYS INVOLVED IN PHEOCHROMOCYTOMA AND PARAGANGLIOMA DEVELOPMENT AND PROGRESSION</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Endocrine Connections
ISSN
2049-3614
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
1538-1549
UT code for WoS article
000751296500005
EID of the result in the Scopus database
2-s2.0-85122300995