8 Paramagnetic Metal Ion Probes for 19F Magnetic Resonance Imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10436143" target="_blank" >RIV/00216208:11110/21:10436143 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/21:10436143
Result on the web
<a href="https://doi.org/10.1515/9783110685701-014" target="_blank" >https://doi.org/10.1515/9783110685701-014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/9783110685701-014" target="_blank" >10.1515/9783110685701-014</a>
Alternative languages
Result language
angličtina
Original language name
8 Paramagnetic Metal Ion Probes for 19F Magnetic Resonance Imaging
Original language description
"Classical" magnetic resonance imaging (MRI) is based on imaging of water protons and the technique is commonly used in clinical and preclinical practice. The 19F nuclide has nuclear magnetic properties similar to those of 1H and can be used for MRI on common commercial scanners with only minor modifications. The 19F MRI is a potentially interesting tool for preclinical or even clinical imaging. As there is no abundance of 19F in a living body, 19F MRI requires contrast agents (CAs) containing fluorine atoms and is presented as "hotspot" imaging. In this text, we present how the current development of 19F MRI CAs is influenced by utilization of paramagnetic metal ions as relaxation agents through shortening the long 19F relaxation times. The theory behind the change of relaxation times is briefly introduced. Influence of lanthanide(III) and transition metal ions on the relaxation properties of the 19F nucleus in defined molecules and in nanoobjects is reviewed and differences between complexes of these two metal ion families are discussed. The 19F tracers are best utilized as responsive MRI CAs and various responsive modes of the probes are reviewed and evaluated. As 19F MRI requires some special consideration about acquisition techniques, the main differences between 1H and 19F MRI are discussed. Briefly, some outlook for the technique is suggested.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/LTC17067" target="_blank" >LTC17067: Application of NMR relaxation and diffusion measurements to assess dynamics of complex molecular systems</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Metal Ions in Bio-Imaging Techniques
ISBN
978-3-11-068556-5
Number of pages of the result
32
Pages from-to
239-270
Number of pages of the book
503
Publisher name
Walter de Gruyter GmbH
Place of publication
Berlin, Boston
UT code for WoS chapter
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