Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experimental liver injury

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10438665" target="_blank" >RIV/00216208:11110/21:10438665 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/B978-0-12-814118-2.00014-8" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-814118-2.00014-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-814118-2.00014-8" target="_blank" >10.1016/B978-0-12-814118-2.00014-8</a>

Result language
angličtina
Original language name
Sirtuin 1 mediates hepatoprotective effects of resveratrol-like compounds in experimental liver injury
Original language description
Xenobiotic-induced hepatotoxicity is a particularly important research field for therapeutics. There are numerous hepatotoxins but a limited number of hepatoprotective drugs. Oxidative stress plays a key role in hepatotoxicity. Over the past decade, polyphenols have gained more attention, due to their ameliorative involvement in a myriad of oxidative stress-related diseases. Likewise, the stress-responsive histone deacetylase, sirtuin 1 (SIRT1), has been the focus of the greatest investigation as a potential gateway to the many positive health benefits of polyphenols. In this chapter, we focus on the therapeutic potential of SIRT1-activating compounds in experimental models of xenobiotic-induced hepatotoxicity and the role of SIRT1 in hepatoprotection/hepatotoxicity.
Czech name
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Czech description
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Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease
ISBN
978-0-12-814118-2
Number of pages of the result
14
Pages from-to
295-308
Number of pages of the book
401
Publisher name
Academic Press
Place of publication
Amsterdam
UT code for WoS chapter
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