New Porcine Model of Arteriovenous Fistula Documents Increased Coronary Blood Flow at the Cost of Brain Perfusion
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F22%3A10452908" target="_blank" >RIV/00216208:11110/22:10452908 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/22:10452908
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=6K8t7k1MwJ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=6K8t7k1MwJ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fphys.2022.881658" target="_blank" >10.3389/fphys.2022.881658</a>
Alternative languages
Result language
angličtina
Original language name
New Porcine Model of Arteriovenous Fistula Documents Increased Coronary Blood Flow at the Cost of Brain Perfusion
Original language description
Background: Arteriovenous fistulas (AVF) represent a low resistant circuit. It is known that their opening leads to decreased systemic vascular resistance, increased cardiac output and other hemodynamic changes. Possible competition of AVF and perfusion of other organs has been observed before, however the specific impact of AVF has not been elucidated yet. Previous animal models studied long-term changes associated with a surgically created high flow AVF. The aim of this study was to create a simple AVF model for the analysis of acute hemodynamic changes. Methods: Domestic female pigs weighing 62.6 +- 5.2 kg were used. All the experiments were held under general anesthesia. The AVF was created using high-diameter ECMO cannulas inserted into femoral artery and vein. Continuous hemodynamic monitoring was performed throughout the protocol. Near-infrared spectroscopy sensors, flow probes and flow wires were inserted to study brain and heart perfusion. Results: AVF blood flow was 2.1 +- 0.5 L/min, which represented around 23% of cardiac output. We observed increase in cardiac output (from 7.02 +- 2.35 L/min to 9.19 +- 2.99 L/min, p = 0.0001) driven dominantly by increased heart rate, increased pulmonary artery pressure, and associated right ventricular work. Coronary artery flow velocity rose. On the contrary, carotid artery flow and brain and muscle tissue oxygenation measured by NIRS decreased significantly. Conclusions: Our new non-surgical AVF model is reproducible and demonstrated an acute decrease of brain and muscle perfusion.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/GA20-25429S" target="_blank" >GA20-25429S: Haemodynamic consequences of an arteriovenous fistula for organ perfusion and oxygenation in extreme situations</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Physiology [online]
ISSN
1664-042X
e-ISSN
1664-042X
Volume of the periodical
13
Issue of the periodical within the volume
April
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
881658
UT code for WoS article
000887925400001
EID of the result in the Scopus database
2-s2.0-85131702524