Brain MRI disease burden and sex differences in cognitive performance of patients with multiple sclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F24%3A10467402" target="_blank" >RIV/00216208:11110/24:10467402 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/24:10467402

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=fyTYnL0hGZ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=fyTYnL0hGZ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13760-023-02350-7" target="_blank" >10.1007/s13760-023-02350-7</a>

Result language

angličtina

Original language name

Brain MRI disease burden and sex differences in cognitive performance of patients with multiple sclerosis

Original language description

Background: Although there is evidence that shows worse cognitive functioning in male patients with multiple sclerosis (MS), the role of brain pathology in this context is under-investigated. Objective: To investigate sex differences in cognitive performance of MS patients, in the context of brain pathology and disease burden. Methods: Brain MRI, neurological examination, neuropsychological assessment (Brief International Cognitive Assessment in MS-BICAMS, and Paced Auditory Verbal Learning Test-PASAT), and patient-reported outcome questionnaires were performed/administered in 1052 MS patients. Results: Females had higher raw scores in the Symbol Digit Modalities Test (SDMT) (57.0 vs. 54.0; p &lt; 0.001) and Categorical Verbal Learning Test (CVLT) (63.0 vs. 57.0; p &lt; 0.001), but paradoxically, females evaluated their cognitive performance by MS Neuropsychological Questionnaire as being worse (16.6 vs 14.5, p = 0.004). Females had a trend for a weaker negative correlation between T2 lesion volume and SDMT (ρ = - 0.37 in females vs. - 0.46 in men; interaction p = 0.038). On the other hand, women had a trend for a stronger correlation between Brain Parenchymal Fraction (BPF) and a visual memory test (Spearman&apos;s ρ = 0.31 vs. 0.21; interaction p = 0.016). All these trends were not significant after correction for false discovery rate. Conclusions: Although, females consider their cognition as worse, males had at a group level slightly worse verbal memory and information processing speed. However, the sex differences in cognitive performance were smaller than the variability of scores within the same sex group. Brain MRI measures did not explain the sex differences in cognitive performance among MS patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Neurologica Belgica

ISSN

0300-9009

e-ISSN

2240-2993

Volume of the periodical

124

Issue of the periodical within the volume

1

Country of publishing house

BE - BELGIUM

Number of pages

10

Pages from-to

109-118

UT code for WoS article

001044705200001

EID of the result in the Scopus database

2-s2.0-85167360190