Methoxetamine and its metabolites: Postmortem determination in body fluids of human cadaver

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F24%3A10478661" target="_blank" >RIV/00216208:11110/24:10478661 - isvavai.cz</a>

Alternative codes found

RIV/61383082:_____/24:00001402

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=oGATEMVjjl" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=oGATEMVjjl</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/jat/bkad084" target="_blank" >10.1093/jat/bkad084</a>

Result language

angličtina

Original language name

Methoxetamine and its metabolites: Postmortem determination in body fluids of human cadaver

Original language description

We report the forensic case of a 42-year-old man, a known drug user, who died at home and whose body was only discovered 2 months later. Autopsy was performed on a corpse in the late postmortem stage where no apparent cause of death was found. A toxicological screening of biological materials (blood, urine and gastric content) using liquid chromatography with different types of mass detection (ion trap and high-resolution) revealed the presence of methoxetamine (MXE), a ketamine analog, and its metabolites. MXE and a number of its metabolites (e.g., O-desmethyl, N-desethyl, hydroxy, glucuronides and sulfates) were identified in urine. Based on the results, a method using liquid chromatography with tandem mass spectrometry was developed and validated for the determination of MXE concentration in biological materials. The following values of MXE concentration were found: blood-3.6 ng/mL, urine-70.5 ng/mL and gastric content-18.0 ng/mL. Given the absence of other drugs, medications and poisons, it can be inferred that despite relatively low blood concentrations, MXE contributed to the victim&apos;s death. The present case demonstrates that even after 2 months, MXE and its several metabolites can be detected and determined in the human cadaver at a relatively advanced stage of decomposition.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/VI20192022168" target="_blank" >VI20192022168: Elaboration of methodology for screening and confirmation of synthetic cannabinoids in biological material</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Analytical Toxicology

ISSN

0146-4760

e-ISSN

1945-2403

Volume of the periodical

48

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

70-74

UT code for WoS article

001184129400001

EID of the result in the Scopus database

2-s2.0-85184044248