CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F24%3A10479910" target="_blank" >RIV/00216208:11110/24:10479910 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/24:10479910
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=esVRDRq47W" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=esVRDRq47W</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/antiox13020191" target="_blank" >10.3390/antiox13020191</a>
Alternative languages
Result language
angličtina
Original language name
CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease
Original language description
The progress in understanding the pathogenesis and treatment of Alzheimer's disease (AD) is based on the recognition of the primary causes of the disease, which can be deduced from the knowledge of risk factors and biomarkers measurable in the early stages of the disease. Insights into the risk factors and the time course of biomarker abnormalities point to a role for the connection of amyloid beta (A beta) pathology, tau pathology, mitochondrial dysfunction, and oxidative stress in the onset and development of AD. Coenzyme Q(10) (CoQ(10)) is a lipid antioxidant and electron transporter in the mitochondrial electron transport system. The availability and activity of CoQ(10) is crucial for proper mitochondrial function and cellular bioenergetics. Based on the mitochondrial hypothesis of AD and the hypothesis of oxidative stress, the regulation of the efficiency of the oxidative phosphorylation system by means of CoQ(10) can be considered promising in restoring the mitochondrial function impaired in AD, or in preventing the onset of mitochondrial dysfunction and the development of amyloid and tau pathology in AD. This review summarizes the knowledge on the pathophysiology of AD, in which CoQ(10) may play a significant role, with the aim of evaluating the perspective of the pharmacotherapy of AD with CoQ(10) and its analogues.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/NU23-04-00032" target="_blank" >NU23-04-00032: Mitochondrial toxicity of tau protein oligomers and its regulation by drugs for Alzheimer's disease</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Antioxidants
ISSN
2076-3921
e-ISSN
2076-3921
Volume of the periodical
13
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
21
Pages from-to
191
UT code for WoS article
001175122800001
EID of the result in the Scopus database
2-s2.0-85187290279