Virological characteristics of the SARS-CoV-2 JN.1 variant
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F24%3A10479945" target="_blank" >RIV/00216208:11110/24:10479945 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KQpDYN0CCq" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=KQpDYN0CCq</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S1473-3099(23)00813-7" target="_blank" >10.1016/S1473-3099(23)00813-7</a>
Alternative languages
Result language
angličtina
Original language name
Virological characteristics of the SARS-CoV-2 JN.1 variant
Original language description
The SARS-CoV-2 BA.2.86 lineage, first identified in August 2023, is phylogenetically distinct from the current circulating SARS-CoV-2 omicron XBB lineages, including EG.5.1 and HK.3. Compared with XBB and BA.2, BA.2.86 carries more than 30 mutations in the spike protein, indicating a high potential for immune evasion. BA.2.86 has evolved and its descendant, JN.1 (BA.2.86.1.1), emerged in late 2023. JN.1 harbours Leu455Ser and three mutations in non-spike proteins. Spike protein mutation Leu455Ser is a hallmark mutation of JN.1: we have recently shown that HK.3 and other flip variants carry Leu455Phe, which contributes to increased transmissibility and immune escape ability compared with the parental EG.5.1 variant. Here, we investigated the virological properties of JN.1.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Lancet: Infectious Diseases
ISSN
1473-3099
e-ISSN
1474-4457
Volume of the periodical
24
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
1
Pages from-to
"e82"
UT code for WoS article
001176063700001
EID of the result in the Scopus database
2-s2.0-85183007420