Lipid and brain volumetric measures in multiple sclerosis patients: findings from a large observational study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F24%3A10488501" target="_blank" >RIV/00216208:11110/24:10488501 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/24:10488501

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.n3PoMFGri" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.n3PoMFGri</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13760-024-02676-w" target="_blank" >10.1007/s13760-024-02676-w</a>

Result language

angličtina

Original language name

Lipid and brain volumetric measures in multiple sclerosis patients: findings from a large observational study

Original language description

Objectives This study aimed to investigate relationships between cholesterol profile, brain volumetric MRI, and clinical measures in a large observational cohort of multiple sclerosis (MS) patients. Materials and methods We included 1.505 patients with 4.966 time points including complete lipid, clinical, and imaging data. The time among lipid, brain MRI and clinical measures was under 90 days. Cross-sectional statistical analysis at baseline was performed using an adjusted linear regression and analysis of longitudinal lipid and MRI measures data was performed using adjusted linear mixed models. Results We found associations between higher high-density lipoprotein cholesterol (HDL-C) and lower brain parenchymal fraction (BPF) at cross-sectional analysis at baseline (B = -0.43, CI 95%: -0.73, -0.12, p = 0.005), as well as in longitudinal analysis over follow-up (B = -0.32 +/- 0.072, chi(2) = 36.6; p = &lt; 0.001). Higher HDL-C was also associated with higher T-2-lesion volume in longitudinal analysis (B = 0.11 +/- 0.023; chi(2) = 23.04; p = &lt; 0.001). We observed a weak negative association between low-density lipoprotein cholesterol (LDL-C) levels and BPF at baseline (B = -0.26, CI 95%: -0.4, -0.11, p = &lt; 0.001) as well as in longitudinal analysis (B = -0.06 +/- 0.03, chi(2) = 4.46; p = 0.03). T2-LV did not show an association with LDL-C. We did not find any association between lipid measures and disability. The effect of lipid levels on MRI measures and disability was minimal (Cohen f2 &lt; 0.02). Conclusions Our results contradict the previously described exclusively positive effect of HDL-C on brain atrophy in patients with MS. Higher LDL-C was weakly associated with higher brain atrophy but not with higher lesion burden.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Neurologica Belgica

ISSN

0300-9009

e-ISSN

2240-2993

Volume of the periodical

124

Issue of the periodical within the volume

6

Country of publishing house

BE - BELGIUM

Number of pages

8

Pages from-to

1981-1988

UT code for WoS article

001342173300005

EID of the result in the Scopus database

2-s2.0-85207325028