Immunotherapy in head and neck cancers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F24%3A10489540" target="_blank" >RIV/00216208:11110/24:10489540 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=M~_XMmjN6U" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=M~_XMmjN6U</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/ccorl2024233" target="_blank" >10.48095/ccorl2024233</a>

Result language

angličtina

Original language name

Immunotherapy in head and neck cancers

Original language description

Immunotherapy is a promising therapeutic modality that has rapidly gained its place in the treatment of many malignancies. The assumption of its effect in head and neck tumors stems from the high mutational load of these tumors. Phase I clinical trials were consistent with preclinical assumptions. Subsequent phase II and III trials confirmed the efficacy of the check-point inhibitors nivolumab (OPDIVO) in second-line palliation, and in the case of pembrolizumab, in first-line treatment of recurrent and metastatic head and neck cancer. In the Czech Republic, the use of pemobrolizumab was approved in 2014. In clearly defined indications, pembrolizumab therapy (Keytruda) is now also covered by public health insurance. However, in the Czech Republic, surgical treatment followed by adjuvant oncological treatment still remains the gold standard in the first-line treatment of head and neck cancer. Nevertheless, the approach is always individual and the best treatment modality is chosen based on the extent of the primary disease and the overall condition and preferences of the patient.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30206 - Otorhinolaryngology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Otorinolaryngologie a foniatrie

ISSN

1210-7867

e-ISSN

1805-4528

Volume of the periodical

73

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

233-238

UT code for WoS article

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EID of the result in the Scopus database

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