Homocysteine enhances the excitability of cultured hippocampal neurons without altering the gene expression of voltage-gated ion channels
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10497263" target="_blank" >RIV/00216208:11110/25:10497263 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43928357
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Zv_B5h4lat" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Zv_B5h4lat</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13041-025-01205-x" target="_blank" >10.1186/s13041-025-01205-x</a>
Alternative languages
Result language
angličtina
Original language name
Homocysteine enhances the excitability of cultured hippocampal neurons without altering the gene expression of voltage-gated ion channels
Original language description
Elevated plasma homocysteine (Hcy) levels lead to hyperhomocysteinemia, a condition associated with various neurological disorders affecting multiple brain regions, including the hippocampus. In this study, we investigated the effects of exposing cultured rat hippocampal neurons to Hcy concentrations corresponding to mild, moderate, and severe hyperhomocysteinemia. A short 24-hour exposure had minimal effects, whereas prolonged exposure up to 14 days moderately enhanced hippocampal excitability without altering the gene expression of voltage-dependent calcium, sodium, or potassium channels or intracellular calcium levels. These findings suggest that Hcy-induced changes in neuronal excitability may contribute to neuropathologies associated with hyperhomocysteinemia.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/EF19_073%2F0016935" target="_blank" >EF19_073/0016935: Grant schemes at Charles University</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Brain
ISSN
1756-6606
e-ISSN
1756-6606
Volume of the periodical
18
Issue of the periodical within the volume
April
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
31
UT code for WoS article
001463544500001
EID of the result in the Scopus database
2-s2.0-105003323849