Long-term frailty and physical performance transitions in older people with type-2 diabetes. The MIDFRAIL randomized clinical study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10497681" target="_blank" >RIV/00216208:11110/25:10497681 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-9vJFcpnfQ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-9vJFcpnfQ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jnha.2025.100512" target="_blank" >10.1016/j.jnha.2025.100512</a>
Alternative languages
Result language
angličtina
Original language name
Long-term frailty and physical performance transitions in older people with type-2 diabetes. The MIDFRAIL randomized clinical study
Original language description
Aims: Type 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after >=18 months of intervention. Methods: 298 community-dwelling older adults (>70 years) participating in MIDFRAIL followed-up for 18-24 months were randomly allocated by trial site (cluster) to intervention IG (16-weeks resistance exercise program, nutritional-educational sessions, optimization of diabetes care), or usual care group (UCG). Frailty status was assessed by the Fried Frailty Phenotype criteria at baseline and final visit. Functional status was assessed by the SPPB in every visit. We used multivariate linear and logistic regression for continuous and dichotomous outcomes. This study was registered at Clinicaltrials.gov (NCT01654341). Results: Mean age was 77.7 (SD 5.54), 47% were male, 32.9% frail and 67.1% prefrail. The probability of improving the frailty status and decreasing the number of Fried's frailty criteria was higher in the IG than in the UCG (OR 2.6, 95%CI 1.3-5.4; p = 0.009 and OR 1.9; 95%CI 1.1-3.1; p = 0.02, respectively). IG participants more frequently improved >=1 point in SPPB score (OR 1.85; 95%CI 1.09-3.12; p = 0.022). These benefits were mainly accounted for the prefrail participants. Conclusions: The MIDFRAIL intervention improved frailty status and physical function at long-term follow-up in older people with T2D.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30227 - Geriatrics and gerontology
Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Nutrition, Health and Aging
ISSN
1279-7707
e-ISSN
1760-4788
Volume of the periodical
29
Issue of the periodical within the volume
4
Country of publishing house
FR - FRANCE
Number of pages
7
Pages from-to
100512
UT code for WoS article
001434618000001
EID of the result in the Scopus database
2-s2.0-85217980883