The role of comprehensive geriatric assessment in older patients affected by knee osteoarthritis: an exploratory randomized controlled trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10498539" target="_blank" >RIV/00216208:11110/25:10498539 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Cal802j-F5" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Cal802j-F5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s40520-025-03061-0" target="_blank" >10.1007/s40520-025-03061-0</a>
Alternative languages
Result language
angličtina
Original language name
The role of comprehensive geriatric assessment in older patients affected by knee osteoarthritis: an exploratory randomized controlled trial
Original language description
Objectives: This study aimed to assess the effectiveness of Comprehensive Geriatric Assessment (CGA) compared to standard of care in improving pain, physical function, and stiffness in older adults with knee osteoarthritis (OA) over six months. Secondary outcomes included multidimensional frailty and quality of life. Design: An exploratory, multicentre, randomized controlled trial (RCT). Setting: Five European geriatric centres in Italy, Germany, Turkiye and the Czech Republic. Participants: Seventy older adults (mean age 76.1 +- 6.8 years; 80% female) with knee OA (Kellgren-Lawrence Grades 1-2) were randomized into two groups: CGA (n = 35) or standard of care (n = 35). Intervention: The CGA group underwent a multidimensional geriatric assessment and intervention, identifying impairments and tailoring interventions accordingly, while the control group received standard of care. Main outcome measures: The primary endpoint was improvement in pain, stiffness, and functional limitations measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) over six months. Secondary outcomes included changes in multidimensional frailty (Multidimensional Prognostic Index, MPI), quality of life (SF-36), and adherence to interventions. Results: The CGA group showed a non-significant improvement in total WOMAC scores (-4.49 +- 3.40, p = 0.19), with slight reductions in pain (-1.12 +- 0.96) and functional limitations (-3.26 +- 2.21). MPI slightly improved (-0.02 +- 0.04, p = 0.69), but no significant changes were observed in SF-36 scores. No falls, hospitalizations, or severe adverse events were reported. Conclusions: CGA may offer potential benefits for managing knee OA in older adults, particularly for pain and function, though statistical significance was not achieved. Larger studies with longer follow-up are warranted to confirm these findings.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30227 - Geriatrics and gerontology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Aging: Clinical and Experimental Research
ISSN
1594-0667
e-ISSN
1720-8319
Volume of the periodical
37
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
155
UT code for WoS article
001489850700003
EID of the result in the Scopus database
2-s2.0-105005437182