Effect of Methylprednisolone on Ischemic Brain Edema After Temporary Occlusion of the Middle Cerebral Artery in Rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10506732" target="_blank" >RIV/00216208:11110/25:10506732 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WvaIzhcCWv" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WvaIzhcCWv</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.935600" target="_blank" >10.33549/physiolres.935600</a>
Alternative languages
Result language
angličtina
Original language name
Effect of Methylprednisolone on Ischemic Brain Edema After Temporary Occlusion of the Middle Cerebral Artery in Rats
Original language description
We studied the effect of Methylpredisolone (MP) on ischemic brain edema after temporary occlusion of the middle cerebral artery for 90 min (MCAo90). We verified the presence of ischemic edema by determining the brain water content (BWC) by measuring dry/wet weight and by examining MRI-T2-weighted imaging, T2 relaxation times and apparent diffusion coefficient (ADC). In another group, animals were administered MP intraperitoneally 30 min after MCAo90, followed by 24 h reperfusion (MCAoMP). Edema changes were documented by the same MRI examinations. A statistically significant increase in BWC was found between the post-MCAo90 group of animals and the intact animals, demonstrating the presence of edema in the former group. A statistically significant increase in ADC was observed in the MCAo group, indicating the presence of vasogenic edema. A statistically significant difference was demonstrated between the MCAo and MCAoMP groups, with no statistically significant difference between the CG and MCAoMP groups, demonstrating a reduction in ischemic brain swelling after MP administration. The main effect of MP on ischemic brain edema is attributed to its antioxidant capacity. It can be assumed that this capacity of MP, with its complex impact on cellular metabolism, affects the movement of water in the brain and reduces ischemic brain edema.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
1802-9973
Volume of the periodical
74
Issue of the periodical within the volume
5
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
9
Pages from-to
861-869
UT code for WoS article
001631813000014
EID of the result in the Scopus database
2-s2.0-105020864360