Narcolepsy and circadian rhythm disorders: diagnosis and management
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10506822" target="_blank" >RIV/00216208:11110/25:10506822 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/B978-0-443-30004-2.00014-6" target="_blank" >https://doi.org/10.1016/B978-0-443-30004-2.00014-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-443-30004-2.00014-6" target="_blank" >10.1016/B978-0-443-30004-2.00014-6</a>
Alternative languages
Result language
angličtina
Original language name
Narcolepsy and circadian rhythm disorders: diagnosis and management
Original language description
There is increasing evidence that circadian rhythm abnormalities are involved in the pathophysiology of narcolepsy. The primary circadian pacemaker, the suprachiasmatic nucleus, has a strong influence on hypocretin release. Experimental data have demonstrated the existence of functional hypocretin neurons and a pineal gland circuit able to modulate melatonin production. Clinical data support altered circadian rhythm of melatonin concentration in some hypocretin-deficient patients with a potential connection to daytime sleepiness and abnormal circadian rhythm of body temperature. Clinical manifestations of the disease suggest some circadian aspects as well. Comorbidity of narcolepsy with primary circadian sleep-wake disorders is extremely rare; however, daytime sleepiness may be seen in almost all circadian sleep-wake rhythm disorders with varying severity and timing. Excessive daytime sleepiness and/or difficulties with nocturnal sleep may present differential diagnostic challenges and should be verified by objective examination: most frequently by actigraphy, if necessary, by polysomnography and multiple sleep latency test. Therapeutic approaches include behavioral and pharmaceutical procedures, while melatonin receptor agonists and dual orexin receptor agonists may represent future trends.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Narcolepsy: Integrating Basic and Clinical Knowledge
ISBN
978-0-443-30004-2
Number of pages of the result
14
Pages from-to
251-264
Number of pages of the book
646
Publisher name
Academic Press
Place of publication
Amsterdam
UT code for WoS chapter
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