An unusual case of late recurrent adult granulosa cell tumor and mature teratoma arising within the same ovary, confirmed by NGS analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10508068" target="_blank" >RIV/00216208:11110/25:10508068 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/25:10508068
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Rme.J77yU3" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Rme.J77yU3</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
An unusual case of late recurrent adult granulosa cell tumor and mature teratoma arising within the same ovary, confirmed by NGS analysis
Original language description
Adult granulosa cell tumor is a predominant malignant tumor among ovarian sex cord-stromal tumors, representing approximately 3-5% of all ovarian malignancies and being known for its risk of recurrence with high mortality rate. We present a unique case of a 71-year-old woman with, to our knowledge, the first documented instance of a recurrent AGCT arising concurrently with a mature ovarian teratoma, confirmed through both immunohistochemistry and molecular biological analysis. The tumor in both the primary and recurrent lesion harbored a missense FOXL2 mutation typical for adult granulosa cell tumor. TP53, TSC2 and RB1 mutations were present only in the recurrent tumor, indicating secondary mutations acquired during progression.
Czech name
—
Czech description
—
Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
—
OECD FORD branch
30109 - Pathology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Česko-slovenská patologie a Soudní lékařství
ISSN
1210-7875
e-ISSN
1805-4498
Volume of the periodical
61
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
206-209
UT code for WoS article
—
EID of the result in the Scopus database
2-s2.0-105030225827