The Novel Functions of M4 Muscarinic Receptors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10508441" target="_blank" >RIV/00216208:11110/25:10508441 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=apqTqOPpXj" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=apqTqOPpXj</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.935750" target="_blank" >10.33549/physiolres.935750</a>
Alternative languages
Result language
angličtina
Original language name
The Novel Functions of M4 Muscarinic Receptors
Original language description
The role of M4 muscarinic receptors in locomotor activity regulation remains controversial, with conflicting findings hampering our understanding of movement disorders. This uncertainty is further complicated by the unexplored relationship between M4 receptors and biological rhythms, as well as potential sex-specific effects that may explain previous inconsistent results. Through systematic investigation of locomotor functions in biological rhythm paradigms, we discovered that M4 muscarinic receptors significantly modulate locomotor activity rhythms via brain pacemaker mechanisms. Notably, this regulatory effect displayed marked sexual dimorphism, being present exclusively in females, suggesting crucial interactions with sex hormones. Our research identified the striatum as the key structure directing these locomotor biological rhythms. These findings provide critical insights into the sex-specific nature of M4 receptor function and establish a new framework for understanding hyperactivity disorders, particularly those exhibiting sex-based differences in prevalence or manifestation. Key words M4 muscarinic receptors " M1 muscarinic receptors " Biological rhythm " Locomotor activity " Striatum.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
1802-9973
Volume of the periodical
74
Issue of the periodical within the volume
Suppl 1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
18
Pages from-to
"S1"-"S18"
UT code for WoS article
001690902000001
EID of the result in the Scopus database
2-s2.0-105027043543