Prenatal methotrexate exposure delays onset of low Mg2+-induced epileptiform discharges in the entorhinal cortex

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F00%3A00003621" target="_blank" >RIV/00216208:11120/00:00003621 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/s0165-3806(00)00085-7" target="_blank" >http://dx.doi.org/10.1016/s0165-3806(00)00085-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/s0165-3806(00)00085-7" target="_blank" >10.1016/s0165-3806(00)00085-7</a>

Result language
angličtina
Original language name
Prenatal methotrexate exposure delays onset of low Mg2+-induced epileptiform discharges in the entorhinal cortex
Original language description
We determined the effects of prenatal exposure to DNA synthesis inhibitor methotrexate (MTX) on: (a) the susceptibility to low Mg2+-induced epileptiform activity in deep layers (IV-V) of medial entorhinal cortex in vitro; and (b) neuronal counts in thisarea. Low Mg2+-induced discharges developed significantly later in slices from prenatally MTX-exposed rats than in control slices. Neuronal counts were increased in the layer V of medial entorhinal cortex of prenatally MTX-exposed rats. Results indicatethat: (a) MTX-induced prenatal brain DNA impairment is antiepileptogenic; and (b) simple increases in neuronal numbers may not be associated with epileptogenic effects.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
—

Project
<a href="/en/project/IZ3613" target="_blank" >IZ3613: Effects of repeated seizures and long-term antiepileptic therapy on brain morphology and function</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2000
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)