Prenatal methotrexate exposure decreases seizure susceptibility in young rats of two strains
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F00%3A00003622" target="_blank" >RIV/00216208:11120/00:00003622 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1006/exnr.1999.7318" target="_blank" >http://dx.doi.org/10.1006/exnr.1999.7318</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1006/exnr.1999.7318" target="_blank" >10.1006/exnr.1999.7318</a>
Alternative languages
Result language
angličtina
Original language name
Prenatal methotrexate exposure decreases seizure susceptibility in young rats of two strains
Original language description
Effects of prenatal exposure to methotrexate (MTX) administered in Sprague-Dawley (one 5 mg/kg dose of MTX on gestational day 15; E15) or Wistar (one 5 mg/kg dose of MTX on E14 or E15 or two such doses on E15) pregnant rat dams were studied in developingoffspring. Young Sprague-Dawley rats were subjected to rapid kindling on postnatal days (PN) 15 and 16, and to flurothyl seizures on PN 15 and PN 30, Offspring of the Wistar strain were tested in flurothyl on PN 30, In Sprague-Dawley rats, prenatal exposure to MTX decreased susceptibility to kindling-induced seizures on PN 15 and to flurothyl-induced clonic seizures on PN 30, In Wistar rats, a single dose of MTX on E15 was ineffective, but two doses significantly decreased susceptibility to flurothyl-induced seizures.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/IZ3613" target="_blank" >IZ3613: Effects of repeated seizures and long-term antiepileptic therapy on brain morphology and function</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2000
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Neurology
ISSN
0014-4886
e-ISSN
—
Volume of the periodical
161
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
167-173
UT code for WoS article
000085666300014
EID of the result in the Scopus database
—