Gestational progesterone suppresses embryotoxic action of the complement system to chick embryo

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F01%3A00003806" target="_blank" >RIV/00216208:11120/01:00003806 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Gestational progesterone suppresses embryotoxic action of the complement system to chick embryo

Original language description

In this paper the relation between progesterone levels and embryotoxic effect of serum complement was studied. The aim of this study was to validate hypothesis that progesterone is strong inhibitor of complement embryotoxic action. We used chick embryo like an experimental model for evidence of our hypothesis. We treated chick embryos by sera acquired from healthy pregnant woman with physiologically elevated levels of progesterone and normal complement activity. We investigated embryotoxicity of these sera. We noticed a significant decrease of sera embryotoxicity inversely related to serum levels of progesterone. The embryotoxicity of sera is reversally dependent on progesterone level. These findings bring a new knowledge to the role of progesterone and complement system mainly in initial stages of pregnancy and in some cases of spontaneous abortions.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

22

Issue of the periodical within the volume

1

Country of publishing house

SE - SWEDEN

Number of pages

5

Pages from-to

33-37

UT code for WoS article

000167337500007

EID of the result in the Scopus database

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