Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F02%3A00003696" target="_blank" >RIV/00216208:11120/02:00003696 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo
Original language description
Cisplatin is widely used as an antitumor drug. To reduce its toxic side effects in patients, cisplatin has been bound with procaine in a cisplatin-procaine complex (DPR). The lethal and teratogenic effects of cisplatin alone and of complexcd cisplatin were determined in the chick embryo in ovo in order to compare their influence on rapidly proliferating embryonic tissues. The embryotoxic (lethal + teratogenic) effect was examined after a single intra-amniotic injection of one of six different doses, ranging from 0.03 to30.0 mug, on embryonic days (ED) 3, 4 or 5. The minimal embryotoxic dose was lower for cisplatin alone (0.03-0.3 mug) than for cisplatin in the DPR complex (0.3-3.0 mug), suggesting that cisplatin alone is more embryotoxic than complexedcisplatin. Both substances caused malformations in the surviving embryos evaluated on ED 9. These malformations included microphthalmia, Microcephaly, hypoplasia of the upper and lower jaw, cleft beak, and haemocephaly. Moreover. heart s
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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