Antimutagenic Effect of Ellagic Acid and its Effect on the Immune Response in Mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F02%3A00011166" target="_blank" >RIV/00216208:11120/02:00011166 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Antimutagenic Effect of Ellagic Acid and its Effect on the Immune Response in Mice
Original language description
Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of ellagic acid (EA) against the genotoxicity of three mutagens: aminomethylimidazo-quinoline (IQ), aflatoxin B1 (AFB1), and N-nitroso-N-methylurea (MNU). Ellagic acid is naturally occuring phenolic compound which is found in a variety of soft fruits and vegetables. Effect of this compound on immunosupressive activity of mutagens was followed in vivo by the chemiluminiscence test. In theAmes assay, ellagic acid at concentrations of 300 and 30 g/plate demonstrably inhibits the mutagenic activity of two indirect mutagens: IQ and AFB1. The concentration of 300 g per plate had the strongest effect on mutagenicity of all concentrations of IQ in strain TA 98 of Salmonella typhimurium whereas in strain TA 100, it was 30 g per dish of ellagic acid that was more effective than 300 g/plate. Also in combination with different concentrations of AFB1 ellagic acid was proved to be a
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NJ6138" target="_blank" >NJ6138: Study of antimutagenic effect and immunomodulatory activity of natural substances</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Czech Journal of Food Sciences
ISSN
1212-1800
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
5
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
11
Pages from-to
181-191
UT code for WoS article
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EID of the result in the Scopus database
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