Gemcitabine plus cisplatin vs. gemcitabine plus carboplatin in stage IIIb and IV non-small cell lung cancer: a phase III randomized trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F03%3A00000680" target="_blank" >RIV/00216208:11120/03:00000680 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Gemcitabine plus cisplatin vs. gemcitabine plus carboplatin in stage IIIb and IV non-small cell lung cancer: a phase III randomized trial

Original language description

This randomized, multicenter, phase III trial was conducted to compare the toterability of gemcitabine plus cisplatin (GP) vs. gemcitabine plus carboplatin (GC) in chemonaive patients with stage IIIb and IV non-small cell lung carcinoma (NSCLC). Secondary objectives were to evaluate response, duration of response, time to progressive disease (TTPD), and survival. Patients and methods: Eligible patients were required to have stage IIIb or IV NSCLC, no previous chemotherapy, Karnofsky performance status of at least 70, bidimensionally measurable disease, and age 18-75 years. Randomized patients in both arms were given gemcitabine 1200 mg/m(2) on days 1 and 8, followed on day 1 by cisplatin 80 mg/m(2) (GP) or carboplatin AUC = 5 (GC). Treatment cycles were repeated every 21 days for a maximum of six cycles, or until disease progression or unacceptable toxicity occurred. Results: Enrolled patients in both arms, 87 in GP and 89. in GC, were well balanced for demographics and disease charact

Czech name

Gemcitabin plus cisplatina versus gemcitabin + karboplatina u nemalobuněčného karcinomu plic stadia IIIB a IV. randomizovaná studie 3 fáze.

Czech description

Závěrečná zpráva randomizovaná studie 3. fáze klinického zkoušení srovnávající chemoterapeutickou kombinaci gemcitabin/cisplatina versus gemcitabin/karboplatina u nemocných s pokročilým nemalobuněčným karcinomem plic stadia IIIB nebo IV.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FC - Pneumology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Lung Cancer

ISSN

0169-5002

e-ISSN

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Volume of the periodical

41

Issue of the periodical within the volume

3

Country of publishing house

IE - IRELAND

Number of pages

11

Pages from-to

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UT code for WoS article

000185347600008

EID of the result in the Scopus database

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