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Cortical and striatal mu-opioid receptors are altered by gonadal hormone treatment but not by prenatal morphine exposure in adult male and female rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F03%3A43902595" target="_blank" >RIV/00216208:11120/03:43902595 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.brainresbull.2003.08.002" target="_blank" >http://dx.doi.org/10.1016/j.brainresbull.2003.08.002</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.brainresbull.2003.08.002" target="_blank" >10.1016/j.brainresbull.2003.08.002</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cortical and striatal mu-opioid receptors are altered by gonadal hormone treatment but not by prenatal morphine exposure in adult male and female rats

  • Original language description

    The cerebral cortex (CX), cingulate CX (cgCX), and striatum (STR) play an important role in locomotion, cognition, emotion, and reward-motivated behaviors. and are altered by prenatal morphine exposure. We have demonstrated that delta-opioid receptors inthe CX and STR of adult male and female rats are altered by prenatal morphine exposure and gonadal hormonal treatment. Because morphine binds with greater affinity to mu- than delta-opioid receptors, the present study examined the effect of prenatal morphine exposure on mu-opioid receptor density in the CX, cg-CX. and STR of adult male and female rats using receptor autoradiography. In Experiment 1, three groups of adult male rats were analyzed: intact, gonadally intact; GNX, gonadectomized; and TP, GNX and testosterone propionate (TP)-treated. In Experiment 2, four groups of adult females were analyzed: OVX, ovariectomized; EB, OVX and estradiol benzoate (EB)-treated; P, OVX and progesterone (P)-treated: and EB + P, OVX and EB- and P-

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2003

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Brain Research Bulletin

  • ISSN

    0361-9230

  • e-ISSN

  • Volume of the periodical

    62

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    47-53

  • UT code for WoS article

    000186560600006

  • EID of the result in the Scopus database