Cortical and striatal mu-opioid receptors are altered by gonadal hormone treatment but not by prenatal morphine exposure in adult male and female rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F03%3A43902595" target="_blank" >RIV/00216208:11120/03:43902595 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.brainresbull.2003.08.002" target="_blank" >http://dx.doi.org/10.1016/j.brainresbull.2003.08.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.brainresbull.2003.08.002" target="_blank" >10.1016/j.brainresbull.2003.08.002</a>

Result language

angličtina

Original language name

Cortical and striatal mu-opioid receptors are altered by gonadal hormone treatment but not by prenatal morphine exposure in adult male and female rats

Original language description

The cerebral cortex (CX), cingulate CX (cgCX), and striatum (STR) play an important role in locomotion, cognition, emotion, and reward-motivated behaviors. and are altered by prenatal morphine exposure. We have demonstrated that delta-opioid receptors inthe CX and STR of adult male and female rats are altered by prenatal morphine exposure and gonadal hormonal treatment. Because morphine binds with greater affinity to mu- than delta-opioid receptors, the present study examined the effect of prenatal morphine exposure on mu-opioid receptor density in the CX, cg-CX. and STR of adult male and female rats using receptor autoradiography. In Experiment 1, three groups of adult male rats were analyzed: intact, gonadally intact; GNX, gonadectomized; and TP, GNX and testosterone propionate (TP)-treated. In Experiment 2, four groups of adult females were analyzed: OVX, ovariectomized; EB, OVX and estradiol benzoate (EB)-treated; P, OVX and progesterone (P)-treated: and EB + P, OVX and EB- and P-

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain Research Bulletin

ISSN

0361-9230

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

47-53

UT code for WoS article

000186560600006

EID of the result in the Scopus database

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